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These therapies remain experimental at present because the efficacy of such treatments, as well as their advantage over standard methotrexate protocol, has not been established.

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The most common side effects associated with methotrexate are nauseavomiting and diarrhoeaThese can be avoided by dividing the recommended dose across the day instead of taking the tablets all at onceTaking the tablet dose after meals is also best.

Methotrexate can harm your liverespecially if you also use certain other medicines for infectionstuberculosisdepressionbirth controlhormone replacementhigh cholesterolheart problemshigh blood pressureseizuresor pain or arthritis medicinesincluding acetaminophenTylenolAdvilMotrinand Aleve

Drink plenty of fluids while taking this medication unless your doctor tells you otherwiseDoing so helps your kidneys to remove the drug from your body and avoid some of the side effects.

When used to treat tumorsmethotrexate sometimes causes side effects due to the rapid destruction of cancer cellstumor lysis syndromeTo lower your riskdrink plenty of fluids unless your doctor directs you otherwiseAlsoyour doctor may prescribe an additional medicationTell your doctor right away if you have symptoms such as irregular heartbeatlow back/side painsigns of kidney problemssuch as pink/bloody urinechange in the amount of urinepainful urinationor muscle spasms/weakness.

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